| Effects of PNS on the Hippocampal BDNF expression in sports anemia rats |
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| DOI： |
| EN KeyWords: sports anemia PNS Hippocampal BDNF |
| Fund Project:霍英东教育基金会青年教师基金基础性研究项目（121103） |
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| EN Abstract: |
| Objective: To investigate the effects of sports anemia on the expression of BDNF in rat hippocampi and the roles of PNS in rat nervous system in the sports anemia development. Methods: Twenty-four healthy male 4-week-old SD rats were randomly divided into control group, sports group and PNS intervention group. The rats in both sports group and PNS intervention group were subjected to the increasing load treadmill exercise for 10 weeks, and those in the PNS intervention group were given drug intervention from the fifth week additionally. Hippocampal BDNF mRNA gene expression was detected using real time PCR, and BDNF protein content was determined by ELISA. Results: After ten weeks increasing load treadmill training, the hippocampal BDNF mRNA and protein expression in sports group was significantly lower than in control group and PNS intervention group (P<0.05). Both BDNF mRNA and protein expression showed no significant difference between PNS intervention group and control group. Conclusion: These results suggest that sports anemia may induce brain hypoxic-ischemic injury in rats. The PNS can promote the expression of BDNF in rat hippocampi, which may play a protective role in sports anemia-induced brain hypoxic-ischemic injury. |
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