| Effects of Electroacupuncture at Jiaji (EX-B2) on the expression of actin and tubulin in the rabbit degenerated intervertebral disc |
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| DOI： |
| EN KeyWords: intervertebral disc degeneration electroacupuncture jiaji (EX-B2) actin tubulin |
| Fund Project:2014年湖北省自然科学基金项目（2014CFA088）；2015年国家自然科学基金面上项目（81574072） |
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| EN Abstract: |
| Objective: To observe the effect of electroacupuncture at jiaji (EX-B2) on the expression of actin and tubulin in rabbit degenerated intervertebral disc so as to explore its mechanism in relieving intervertebral disc degeneration. Methods: A total of 40 New Zealand rabbits were randomly divided into normal, model, sham operation and EA groups, 10 rabbits in each group. In the model group, the lumbar intervertebral disc degeneration was established by an axial compression device. The EA group was treated with EA at bilateral jiaji (EX-B2) for 28 days. The expression levels of actin and tubulin in the lumbar intervertebral discs (L4-L5) were assayed by Western blotting at the 28th and 56th day after operation. Results: The expression levels of actin and tubulin on the postoperative day (POD) 28 and 56 in the model group and on the POD 28 in the EA group were significantly declined as compared with the normal group and sham operation group on the POD 28 and 56 (P<0.05). The expression levels of actin and tubulin on the POD 56 in the EA group were significantly increased as compared with those on the POD 28 in the EA group and the model group on the POD 56 (P<0.05). Conclusions: Electroacupuncture at jiaji (EX-B2) could increase the expression levels of actin and tubulin in the rabbit degenerated intervertebral discs and delay the intervertebral disc degeneration by promoting the restoration of the cytoskeleton in the degenerated intervertebral discs. |
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