| Objective: To explore the correlation between the abnormal expression of p-mTOR in the frontal lobe and posttraumatic epilepsy (PTE). Methods: Adult male SD rats were randomly divided into control group (n=6), saline group (n=36) and epilepsy group (n=36). Models were established by injecting FeCl2 into the right frontal lobe. Immunohistochemistry was used to detect the dynamic expression of p-mTOR (Ser2448) in the frontal cortex of rats at different time points (1 h, 24 h, 1 week, 2 weeks, and 4 weeks after modeling). Results: As compared with the saline group, the expression of p-mTOR (Ser2448) in the frontal cortex of the epilepsy group began to increase after 1 h (t=-1.435, P=0.182), reached its maximum after 1 week (t=-4.073, P=0.002), reduced after 2 weeks (t=-2.614, P=0.026) and rose again after 4 weeks (t=-2.506, P=0.031). The difference was statistically significant. Conclusion: The pathogenesis of PTE may be related to the abnormal increase of the expression of p-mTOR (Ser2448) protein in the mTOR signaling pathway. |
