| Objective: By observing the changes in bone mineral density (BMD) and bone metabolism-related indicators, to evaluate the clinical curative effect and discuss the mechanism of ambulation training preventing and treating bone loss after traumatic spinal cord injury. Methods: Twenty-three patients with bone loss after traumatic spinal cord injury were randomly divided into observation group (n=12) and control group (n=11). Two groups were subjected to routine rehabilitation training and drugs. Additionally, the observation group received the ambulation training. The two groups were treated once a day, 10 days for a period of treatment and a total of 6 courses. Lumbar spine and femoral BMD, tartrate resistant acid phosphatase 5b (TRACP5b), bone alkaline phosphatase (BALP), 25-hydroxyitamin D ［25 (OH) D］, blood calcium, blood phosphorus and alkaline phosphatase (ALP) were detected before, and 1 month and 2 months after treatment. Results: After treatment for 2 months, the TRACP5b in observation group was not significantly different before and after treatment. But the TRACP5b in control group was significantly higher than that before the treatment (P<0.05), and the observation group was lower than that in control group (P<0.05). After treatment for 1 and 2 months, bone mineral density of lumbar 4 vertebrae and lumbar 1- lumbar 4 vertebrae of two groups showed a downward trend, but the comparison between intra group or inter group was no different. After treatment for 1 and 2 months, femoral neck and all of femur BMD of two groups showed a downward trend, after 2 months, the femoral neck and femoral BMD of the control group dropped significantly before and after treatment (P<0.05). After treatment for 1 and 2 months, comparison of BALP, 25（OH）D, Blood calcium, Blood phosphorus, ALP between intra group or inter group was no different. Conclusion: Ambulation training can reduce the extent of the BMD decline in femoral neck and all of femur of the patients with traumatic spinal cord injury with different influences on different sublesional bones, which is probably related to inhibition of bone resorption. |
