| Objective: To investigate the intervention of computer-assisted cognitive training in mild cognitive impairment (MCI). Methods: One hundred MCI patients aged 60 years old or over were randomly divided into two group: observation group (50 cases), accepting computer-assisted cognitive training, health education and risk factors control; control group (50 cases), only accepting health education and risk factors control. The computer-assisted cognitive training was given 30 min every time, 3 times every week for 6 months. The cognitive and psychosocial assessments were performed by MoCA and IADL scales at baseline (M0), and 3 months (M3), 6 months (M6), and 12 months (M12) post intervention. Results: The average MoCA scores in the observation group were significantly higher after treatment for 3, 6 and 12 months than those before intervention and control group correspondingly (P<0.01). At M6 and M12, the MoCA scores in the control group were significantly higher than those before intervention (P＜0.01). A crossover effect occurred between the two groups in multiple repeated measures (F=158.6, P<0.01). At M12, the IADL scores in both groups were significantly higher than before intervention (P<0.01), and those in the observation group were significantly higher than in control group (P<0.01). Conclusion: The comprehensive cognitive intervention can effectively improve cognitive deficit, reduce cognitive decline and improve the quality of life. |
