| Effects of repetitive transcranial magnetic stimulation with different frequencies on cognitive impairment in stroke patients |
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| DOI： |
| EN KeyWords: Repetitive transcranial magnetic stimulation Stroke Cognitive function |
| Fund Project:河南省省直医疗机构医疗服务能力提升工程建设项目经费资助（豫财社【2017】149号） |
| 作者 | 单位 | | 丁巧方 | 上海市养志康复医院,上海 201600 | | 李哲 | 郑州大学第五附属医院康复医学科,郑州 450052 | | 郭钢花 | 郑州大学第五附属医院康复医学科,郑州 450052 | | 关晨霞 | 郑州大学第五附属医院康复医学科,郑州 450052 | | 乐琳 | 郑州大学第五附属医院康复医学科,郑州 450052 | | 郝道剑 | 郑州大学第五附属医院康复医学科,郑州 450052 | | 李颖 | 郑州大学第五附属医院康复医学科,郑州 450052 | | 范家宏 | 郑州大学第五附属医院康复医学科,郑州 450052 | | 梁英姿 | 郑州大学第五附属医院康复医学科,郑州 450052 | | 刘绵绵 | 郑州大学第五附属医院康复医学科,郑州 450052 |
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| EN Abstract: |
| Objective: To observe the effects of different frequency repeated transcranial magnetic stimulation (rTMS) on cognitive function and functional independence measure (FIM) in patients with post-stroke cognitive impairment (PSCI). Methods: Sixty patients with PSCI were randomly divided into 5 Hz high frequency group, 1 Hz low-frequency group, 5 Hz + 1 Hz combined group and pseudo-stimulation treatment group, 15 cases in each group for 2 weeks. Montreal Cognitive Assessment Scale (MoCA), auditory Oddball stimulation sequence P300 and functional independence (FIM) were used to evaluate cognitive function and functional independence of patients before and 2 and 8 weeks after treatment. Result: After 2 weeks of treatment and 8 weeks of follow-up, MoCA scores in the high frequency group, the low-frequency group and the combined group were significantly higher than those before treatment and the control group (P<0.05), the incubation period in the 3 groups at 2 time points was shorter than that before treatment, and the amplitude and cognitive function scores were higher than those before treatment (P<0.05). The incubation period and amplitude in the high frequency group and the combined group were significantly reduced as compared with those in the control group (P<0.05), and the total score of FIM was higher than that before treatment (P<0.05). MoCA score and cognitive function score in the combined group were significantly higher than those in the low-frequency group and the high-frequency group (P<0.05), and the latency period was significantly shorter and the amplitude was significantly greater than those in the low-frequency group (P<0.05). After 2 weeks of treatment, the cognitive function score and FIM total score in the combined group were significantly higher than those in the control group (P<0.05). After 8 weeks of follow-up, the latency period in the low-frequency group was shorter than that in the control group, and the amplitude and cognitive function score were significantly higher (P<0.05). The combined group had lower latency and higher amplitude than in the high-frequency group, and the motor function score was significantly higher than in the low frequency group and the high frequency group (P<0.05). The motor function score in the high-frequency group and the combined group was significantly higher than that before treatment, and the total FIM score was significantly higher than that at 2nd week after treatment (P<0.05). The total FIM scores in low-frequency group and control group were significantly higher than those before treatment (P<0.05). Conclusion: The effect of combined magnetic stimulation therapy on cognitive function and life independence was earlier and more persistent than that of single frequency magnetic stimulation therapy. |
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