| Objective: To observe the effects of different frequency repeated transcranial magnetic stimulation (rTMS) on cognitive function and functional independence measure (FIM) in patients with post-stroke cognitive impairment (PSCI). Methods: Sixty patients with PSCI were randomly divided into 5 Hz high frequency group, 1 Hz low-frequency group, 5 Hz + 1 Hz combined group and pseudo-stimulation treatment group, 15 cases in each group for 2 weeks. Montreal Cognitive Assessment Scale (MoCA), auditory Oddball stimulation sequence P300 and functional independence (FIM) were used to evaluate cognitive function and functional independence of patients before and 2 and 8 weeks after treatment. Result: After 2 weeks of treatment and 8 weeks of follow-up, MoCA scores in the high frequency group, the low-frequency group and the combined group were significantly higher than those before treatment and the control group (P<0.05), the incubation period in the 3 groups at 2 time points was shorter than that before treatment, and the amplitude and cognitive function scores were higher than those before treatment (P<0.05). The incubation period and amplitude in the high frequency group and the combined group were significantly reduced as compared with those in the control group (P<0.05), and the total score of FIM was higher than that before treatment (P<0.05). MoCA score and cognitive function score in the combined group were significantly higher than those in the low-frequency group and the high-frequency group (P<0.05), and the latency period was significantly shorter and the amplitude was significantly greater than those in the low-frequency group (P<0.05). After 2 weeks of treatment, the cognitive function score and FIM total score in the combined group were significantly higher than those in the control group (P<0.05). After 8 weeks of follow-up, the latency period in the low-frequency group was shorter than that in the control group, and the amplitude and cognitive function score were significantly higher (P<0.05). The combined group had lower latency and higher amplitude than in the high-frequency group, and the motor function score was significantly higher than in the low frequency group and the high frequency group (P<0.05). The motor function score in the high-frequency group and the combined group was significantly higher than that before treatment, and the total FIM score was significantly higher than that at 2nd week after treatment (P<0.05). The total FIM scores in low-frequency group and control group were significantly higher than those before treatment (P<0.05). Conclusion: The effect of combined magnetic stimulation therapy on cognitive function and life independence was earlier and more persistent than that of single frequency magnetic stimulation therapy. |
