| Objective: To investigate the effects of pulmonary rehabilitation training on the respiratory function, negative emotion, quality of life and survival of non surgical lung cancer patients. Methods: Ninety-eight patients with non-surgical treatment of lung cancer were randomly divided into the rehabilitation training group and the control group. The control group only received routine anti-tumor treatment and rehabilitation. The pulmonary rehabilitation training was conducted in the rehabilitation training group on the basis of the control group, with 1 rehabilitation cycle every 10 weeks for 3 consecutive cycles. Before the intervention, and at 1st and 3rd cycles of intervention, the lung function was detected, and the anxiety and depression were assessed by Self-rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). The quality of life was assessed by the St. George's Respiratory Questionnaire (SGRQ) and the SF-36 Quality of Life Survey (SF-36), and the progression free survival (PFS) and overall survival (OS) were followed up. Results: When the intervention was performed for 1 and 3 cycles, FEV1, FVC and MVV in the rehabilitation training group were significantly higher, and 6 MWT was significantly farther than in the control group (P<0.05). The SAS and SDS scores in the rehabilitation training group were significantly lower than those in the control group at 1st and 3rd cycles of interventions (P<0.05). The SGRQ score in the rehabilitation training group was significantly lower, and the SF 36 score was significantly higher in the 1st and 3rd cycles of interventions than those in the control group (P<0.05). During the intervention period, the complication rate in the rehabilitation training group (8.16%) was significantly lower than that in the control group (26.5%) (P<0.05). The mean follow up period was (24.0±5.6) months, and there was no significant difference in the median PFS and median OS between the rehabilitation training group (15.2 months and 27.2 months) and control group (13.8 months and 25.6 months). Conclusion: Pulmonary rehabilitation training can improve lung function of patients with lung cancer, relieve mood disorders and improve quality of life, but has no significant effect on its survival. |
