| Objective: To investigate the efficacy of transcranial direct current stimulation (tDCS) combined with cognitive training in the improvement of cognitive impairment in Parkinson disease (PD). Methods: Twenty-two patients with Parkinson disease combined with cognitive impairment in our hospital were randomly divided into a control group and tDCS group, n=11 each. The patients in both groups were given the regular anti-Parkinson drug treatment program, and at the same time received computer-aided cognitive rehabilitation training. The tDCS group was treated by tDCS treatment additionally, and the control group was subjected to false stimulation. Before and 4 weeks after treatment, the patients were assessed by the Mini Mental State Scale (MMSE), Montreal Cognitive Assessment Scale (MoCA), Lowenston Cognitive Function Assessment Test (LOTCA) and D2 Attention Scale. Results：After 4 weeks of treatment, the scores of the MMSE, MoCA, LOTCA and D2 attention test scales in the two groups were significantly higher than those before treatment (all P<0.05), and the scores above after treatment in the tDCS group were significantly higher than those in the control group (all P<0.05). Conclusion: The tDCS combined with cognitive training can significantly improve cognitive impairment of patients with PD. |
