| Objective：To explore the effect of aerobic training on pulmonary rehabilitation of patients with COPD in stable stage and the treatment mechanism.Methods: A total of 86 cases of COPD were selected according to the random number table method, the patients were divided into two groups with 43 cases in each group. The control group received conventional treatment of COPD during the stable period. The treatment group was given aerobic training on the basis of treatment in the control group. Before and after 12 weeks of treatment, cardiopulmonary function indicators, interleukin-17 (IL-17), transforming growth factor β1 (TGF- β1), IL-10, vascular endothelial growth factor (VEGF), high mobility group protein 1 (HMGB1), basic fibroblast growth factor (bFGF) and hypoxia-induced factor-1α (HIF-1α) levels, peripheral blood Th17 and Treg contents, and Th17/Treg value were compared between the two groups.Results: After 12 weeks of treatment, the peak VO2 and VEmax in the two groups were significantly higher than those before treatment (all P＜0.01), and those in the treatment group were significantly higher than those in the control group (all P＜0.01), but the VE/CO2 at anaerobic threshold in the two groups was significantly lower than that before treatment (P＜0.01), and that in the treatment group was significantly lower than that in the control group (P＜0.01). The levels of IL-17, VEGF, HMGB1, bFGF, HIF-1α, Th17 and Th17/Treg after treatment in the two groups were significantly lower than those before treatment (all P＜0.01), and those in the treatment group were significantly lower than those in the control group (all P＜0.01), but the levels of TGF-β1, IL-10 and Treg in the two groups were significantly higher than those before treatment (all P＜0.01), and those in the treatment group were significantly higher than those in the control group (all P＜0.01).Conclusion: Aerobic training is beneficial to regulate Th17/Treg cell subgroup imbalance, inhibit inflammatory response, delay pulmonary vascular remodeling, and improve cardiopulmonary function in COPD patients. |
