| Effects of treadmill training on pulmonary function and HMGB-1 expression after spinal cord injury in rats |
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| DOI： |
| EN KeyWords: treadmill training spinal cord injury lung injury high-mobility group box-1 protein |
| Fund Project:国家自然科学基金委员会地区项目（82060419）；贵州省卫生健康委科学技术项目（gzwjkj 2019-1-155）；贵州省科技厅项目（黔科合LG字［2017］7025号） |
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| EN Abstract: |
| Objective: To explore the effect of treadmill training（TT） on lung function and high-mobility group box-1 protein (HMGB1) expression in rats after spinal cord injury（SCI）. Methods: Ninety-six SD female rats were randomly divided into four groups: normal group, sham operation group, SCI group and SCI+TT exercise group. The rats in SCI+TT group began TT on the 3rd day after operation. Arterial blood gas analysis was dpme, and lung wet/dry weight ratio (wet/dry), lung injury score and the expression of HMGB1 in lung tissue were measured on the 3rd day and 14th day after operation. Results: Arterial blood gas analysis showed that PaO2 in SCI+TT group was significantly higher than that in SCI group and PaCO2 was significantly lower than that in SCI group on the 14th day after operation, and wet/dry in lung tissue in SCI+TT group was significantly lower than that in SCI group on the 14th day after operation. The HE staining results showed that compared with the SCI group, the lung injury score of the SCI+TT group was significantly reduced after 14 days (P<0.05). Immunohistochemical results showed that the level of HMGB1 expression in the lung tissues of the SCI group and the SCI+TT group increased significantly after 3 days (P<0.05). Compared with the SCI group, the expression level of HMGB1 of the SCI TT group significantly decreased at 14 days after operation (P<0.05). Conclusion: TT can improve lung dysfunction in rats with SCI in the thoracic segment, and the mechanism may be related to the inhibition of HMGB1 expression. |
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