| Objective: To analyze the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of cognitive dysfunction in patients with hemorrhagic stroke through resting-state functional magnetic resonance imaging (rs-fMRI) technology. Methods: A total of 120 patients with hemorrhagic stroke were randomly divided into study group and control group. In the control group, 60 patients received conventional medical treatment, cognitive function rehabilitation training and high-frequency rTMS false stimulation, and in the study group, 60 patients received conventional medical treatment, cognitive function rehabilitation training and high-frequency rTMS stimulation of the left frontal dorsolateral area. The cognitive function was assessed by Montreal Cognitive Assessment Scale (MoCA) and mini mental state examination (MMSE), and RS fMRI was performed. Results: After 4 weeks of treatment, MOCA score and MMSE score in the two groups were significantly higher than those before treatment, and those in the study group were significantly higher than in the control group (P<0.01). The brain areas with enhanced functional connectivity of dorsolateral left frontal lobe in the study group included the middle frontal gyrus and inferior gyrus, precuneus lobe, inferior temporal gyrus, etc.; The brain regions with higher fractional low frequency amplitude value included inferior frontal gyrus, parahippocampal gyrus, superior temporal gyrus, and the brain regions with increased local consistency value included cingulate gyrus, superior marginal gyrus, and precuneus. After 4 weeks of treatment, the fractional low frequency amplitude and local consistency in the two groups were significantly higher than those before treatment, and those in the study group were sig nificant-ly higher than in the control group (P<0.05). Conclusion: High-frequency rTMS can effectively improve the cognitive function of patients with hemorrhagic stroke. The functional connectivity changes in the cognitive observation area (the left dorsolateral frontal lobe) and the compensatory changes in related brain regions obta-ined by the resting state fMRI analysis confirm the patient’s recognition. |
