Objective:To systematically evaluate the effect of ankle joint mobilization with movement (MWM) on balance and gait function of stroke patients. Methods: AMED, ProQuest,PubMed, Embase, Cochrane Library, Scopus, OpenGray, CNKI, Wanfang and VIP were searched for randomized controlled trials (RCTs) of ankle joint MWM in the treatment of stroke from the establishment of the database to April 2020. The risk bias was evaluated according to Cochrane Handbook, and statistical analysis was performed using Revman 5.3 software after data extraction. Results: A total of 9 RCTs were included in the Meta-analysis, with a total of 214 patients. Meta-analysis results showed that as compared with the control group, the dorsiflexion passive ROM (DF-PROM) [WMD=1.47, 95%CI (1.07, 1.87), P<0.01], gait speed [WMD=8.04, 95%CI (4.80, 11.29), P<0.01], cadence [WMD=10.90, 95%CI (6.31, 15.50), P<0.01], affected stride length [WMD=8.63, 95%CI (5.06, 12.20), P<0.01] and Berg Balance Scale score (BBS) [WMD=4.12, 95%CI (2.64, 5.59), P<0.01] were significantly improved in the ankle joint MWM group. Conclusion: Based on the current evidence, ankle joint mobilization with movement can effectively improve the gait and balance function of stroke patients. Due to the influence of the number and quality of the included literature, more high-quality RCTs are needed to further demonstrate the above conclusions. |