| Objective: To explore the effect of comprehensive intervention model on behavioral and psychological symptoms of patients with Alzheimer’s disease (AD). Methods: Totally, 180 patients with AD were randomized into treatment group (n=90) and control group (n=90). The treatment group received “caregiver-symptom-environment” comprehensive intervention, and the control group received daily care intervention. Behavioral pathology in AD rating scale (BEHAVE-AD) and activity of daily living scale (ADL) were used before intervention and 3 and 6 months after intervention. The incidence of behavioral and psychological symptoms of dementia (BPSD), the rate of taking antipsychotics and the rate of readmission were used to evaluate the overall improvement of patients. Results: After 3 months of treatment, the BEHAVE-AD scores in the two groups were significantly lower than those before treatment (both P<0.01), and the ADL scores in the treatment group were significantly lower than those before treatment (P<0.01), but there was no significant difference in the control group before and after treatment. After 6 months of treatment, the BEHAVE-AD and ADL scores in the two groups were significantly lower than before and after 3 months of treatment (both P<0.01), and after 6 months of treatment in the treatment group, compared with the control group before treatment, and at the same time point after 3 months of treatment, the BEHAVE-AD and ADL scores were significantly reduced (all P<0.01). Conclusions: Comprehensive intervention can reduce the behavioral and psychological symptoms and improve the activity of daily living of patients with AD. |
