| Effects of different intensities of exercises on spasticity and concentration of serum brain-derived neurotrophic factor in patients with incomplete spinal cord injury |
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| DOI： |
| EN KeyWords: spinal cord injury spasticity exercise training brain-derived neurotrophic factor |
| Fund Project:国家自然科学基金面上项目（81672258）；江苏省自然科学基金项目（BK20191182） |
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| EN Abstract: |
| Objective: To observe the effects of different exercise intensities on the levels of lower limb spasticity and the expression of serum brain-derived neurotrophic factor (BDNF) in patients with incomplete spinal cord injury (SCI). Methods: A total of 60 patients with incomplete SCI were randomly divided into 3 groups with 20 cases each. Group A was defined as a control group that was treated with conventional rehabilitation. Group B received low-intensity exercise training to the lower limbs of patients using MOTOmed intelligent training based on the conventional rehabilitation. Group C was given high-intensity training to the lower limbs of patients using MOTOmed intelligent training based on conventional rehabilitation. Spasticity of the lower limbs was assessed by Modified Ashworth Scale (MAS) and Modified Tardieu Scale (MTS) at pre-intervention and the end of 4 weeks’ therapeutic exercises when the concentration of BDNF in the serum was meanwhile tested and analyzed by ELISA. We also conducted correlation analysis among the intensity of exercise, the decrease of spasticity and the growth rate of serum BDNF concentrations. Results: The spasticity level of the lower limbs (AMS and MTS scores) in all three groups decreased after treatment as compared with that before treatment (P<0.05). After intervention, spasticity level (AMS and MTS scores) in group C was significantly lower than that in group A (P<0.05). Serum concentrations of BDNF in groups A and B after 4 weeks of treatment were increased as compared with those before treatment (P<0.05). The serum BDNF concentration after treatment in group C was significantly higher than that in groups A and B (P<0.05). There was a positive correlation between exercise intensity, the decrease of spasticity (MAS and MTS scores) and the increased rate of serum BDNF concentrations. Conclusions: Performing exercise, especially in high-intensity mode, could improve the spasticity of the lower limbs in patients with incomplete SCI. The content of serum BDNF can also be increased. Moreover, there is a positive correlation between the intensity of exercise, the decrease of spasticity and the increased rate of serum BDNF concentrations. |
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