| Objective: To investigate the analgesic effect of repetitive transcranial magnetic stimulation (rTMS) on patients with cancer pain. Methods: In this prospective randomized controlled trial, 50 patients with cancer pain were randomly divided into rTMS group and control group. On the basis of routine drug therapy, the rTMS group was treated with high frequency 10 Hz and left dorsolateral prefrontal cotex stimulation, while the control group was treated with sham stimulation. The therapeutic effect was evaluated by NRS digital score, oral equivalent dose of morphine (OME) and WHO quality of life scale (WHOQOL-BREF). Results: After 2 weeks of treatment, the NRS scores in the rTMS group were significantly lower than those before treatment and the control group after treatment (P<0.05), but there was no significant difference in the control group before and after treatment. After treatment, the OME of both groups increased as compared with that before treatment, but the increased dose of rTMS group was significantly lower than that of the control group (P<0.05). After treatment, the total scores of WHOQL-BREF in the two groups were significantly higher than those before treatment, but the total score in the rTMS group was higher than that in the control group (P<0.05). After treatment, the effective rate (NRS improvement ≥30% or 50%) in the rTMS group was significantly higher than that in the control group (P<0.05). Conclusion: rTMS can significantly relieve the pain degree of patients with cancer pain, reduce the dosage of analgesics, and improve the quality of life of patients with cancer pain. It may be an effective tool for rehabilitation treatment of cancer pain. |
