| Objective: To explore the effect of computer-assisted cognitive training (CACR) on serum neurological function related indexes and living ability in patients with cognitive impairment after stroke. Methods: All 80 patients with cognitive dysfunction after stroke admitted to our hospital were randomly divided into the control group (n=40) and the experimental group (n=40). All patients received routine therapy. Besides, the control group was given occupational therapy, and the experimental group was subjected to CACR. Before and 3 months after the intervention, the Mini-Mental State Evaluation (MMSE) was used to evaluate the cognitive function, and the modified Barthel Index (MBI) to assess the living ability. The levels of serum Visinin-like protein-1 (VILIP-1), glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) were detected. Results: After the intervention, the MMSE and MBI scores in the two groups were significantly higher than those before the intervention (P<0.05), and those in the experimental group were significantly higher than in the control group (P<0.05); the levels of serum VILIP-1, GFAP, and NSE in the two groups were significantly lower than those before the intervention (P<0.05), and those in the experimental group were significantly lower than in the control group (P<0.05). Conclusion: The intervention of CACR combined with occupational therapy for patients with cognitive dysfunction after CS can effectively down-regulate the expression of serum VILIP-1, GFAP, and NSE, significantly improve the cognitive function of patients, and significantly improve their living ability. |
