| Objective: To investigate the efficacy of resistance training combined with computerized cognitive training (CCT) for mild cognitive impairment (MCI) after stroke. Methods: A total of 116 patients with post-stroke mild cognitive impairment admitted to the First Hospital of Zhangjiakou city from August 2018 to August 2021 were selected. The patients were divided into control group and observation group by random number table method, with 58 cases in each group. The control group received CCT training for 8 weeks, and the observation group received resistance training combined with CCT training for 8 weeks. The differences in cognitive function, attention and executive function, memory function, living ability, serum brain-derived neurotrophic factor (BDNF), neuron specific enolase (NSE), C-reactive protein (CRP), interleukin-6 (IL-6) and IL-10 were compared between the two groups. Results: After training, MMSE score, MoCA score, RBMT score, BI index, serum BDNF and NSE levels were higher than before training (P<0.05), and the time to complete the sorting of digital cards was shorter than before training (P<0.05). Serum CRP, IL-6 and IL-1β levels were lower than those before training (P<0.05). MMSE score, MoCA score and RBMT score, BI index, serum BDNF, NSE in the observation group after training was significantly higher than those in the control group (P<0.05). The sorting time of digital cards, serum CRP, IL-6 and IL-1β in the observation group were lower than those in the control group (P<0.05). Conclusion: Anti-resistance training combined with CCT can effectively reduce the level of serum inflammatory factors and increase the level of serum neurofactors in patients with mild cognitive impairment after stroke, improve the cognitive, attention, executive and memory functions, and improve life ability. |
