| Objective: To explore the effects of mirror therapy combined with action observation therapy on upper limb function and expressions of serum tau protein and glial cell line-derived neurotrophic factor (GDNF) in stroke hemiplegic patients. Methods: A total of 135 patients with hemiplegia after stroke were divided into control group 1, control group 2 and study group according to the random number table method. During the study period, 2 cases fell off in each group, and 43 cases were included in each group. All patients received rehabilitation treatment. On this basis, the control group 1 received mirror therapy, the control group 2 received action observation therapy, and the study group received mirror therapy combined with action observation therapy. Neurological function recovery, upper limb function, activities of daily living, serum Tau protein and GDNF expression levels were compared among the three groups. Results: After treatment, the scores of CNDS in the three groups were lower than those before treatment (P<0.05), and the CNDS score in the study group was lower than that in the control groups 1 and 2 (P<0.05). The upper extremity function score in Fugl Meyer motor function score (FMA) and Barthel index (BI) score after treatment in the three groups were higher than those before treatment (P<0.05), and the upper limb function score and BI score in study group were higher than those in control groups 1 and 2 (P<0.05). The expression level of serum tau protein after treatment in the three groups was lower than that before treatment (P<0.05), and that of serum Tau protein was lower (P<0.05) and the serum GDNF level was higher (P<0.05) after treat-ment in the study group than in control groups 1 and 2. Conclusion: The mirror therapy combined with action observation therapy can significantly reduce the degree of neurological deficit, improve the upper limb function and the ability of daily life, and effectively regulate the expression of serum tau protein and GDNF. |
