| Objective: To study the effect of intermittent θ short pulse stimulation (iTBS) combined with action observation therapy on cognitive function of patients with Alzheimer’s disease (AD). Methods： In this controlled trial, 52 patients with mild and moderate AD were selected, and randomly divided into control group (n=26) and observation group (n=26) according to the random number table method.Both groups received conventional drug therapy, cognitive function training and exercise training.The observation group received iTBS combined with action observation therapy (AOT), and the control group only received AOT.The treatment course of both groups was 4 weeks.Monterial cognitive assessment (MoCA) and Simple Mental State Inventory (MMSE) were used to assess cognitive function.The modified Barthel index and functional activity questionnaire (FAQ) were used to evaluate the daily living activities. Results: MMSE score and MoCA score after treatment in the two groups were higher than those before treatment, and the improvement of MMSE score and MoCA score in the observation group was better than that in the control group with the difference being statistically significant (P<0.05).Barthel index score and FAQ score in both groups were higher after treatment than before treatment, and the improvement of Barthel index score and FAQ score in the observation group was higher than that in the control group with statistically significant difference (P<0.05). Conclusion: iTBS combined with action observation therapy can improve the function of mild-to-moderate AD patients and improve their ability of daily living activities, which is worthy of clinical application. |
