| Objective: To investigate the efficacy of low frequency repetitive transcranial magnetic stimulation (LF-rTMS) combined with melodic intonation therapy in the treatment of non-fluent aphasia in the convalescent stage of stroke. Methods: A total of 124 patients with non-fluency aphasia during stroke recovery who were treated in Zhengzhou People’s Hospital from January 2019 to August 2020 were divided into two groups according to a random number table, with 62 cases in each group. The two groups of patients were treated with routine stroke treatment, the control group was treated with LF-rTMS on the basis of drug treatment, and the observation group was given LF-rTMS combined with melodic intonation therapy. The treatment lasted for 4 weeks. The improvement of aphasia symptoms and the score of aphasia quotient (AQ) were evaluated by Western Aphasia Battery (WAB) before and after treatment, the language function was evaluated by Chinese rehabilitation research center aphasia examination (CRRCAE), and the cognitive function was evaluated by Montreal Cognitive Assessment Scale (MoCA). Evoked potentiometer was used to detect event related potential P300 to evaluate the advanced thinking function of brain tissue. Results: Compared with before treatment, the scores of self-speech, retelling, naming and listening comprehension in WAB and the scores of action description and picture description items in CRRCAE after treatment in the two groups significantly increased, and the scores in the observation group were higher than those in the control group (all P<0.05). Compared with before treatment, the scores of AQ and MOCA after treatment in the two groups significantly increased, and those in the observation group were higher than those in the control group (all P<0.05).Com- pared with before treatment, the latency of ERP-P300 after treatment in the two groups was significantly shortened, and that in the observation group was shorter than that in the control group (all P<0.05). The amplitude of ERP-P300 in the two groups significantly increased, and that in the observation group was larger than that in the control group (all P<0.05). Conclusion: LF-rTMS combined with melody and tone therapy can significantly improve the language function and language expression ability of patients with non-fluent aphasia during stroke recovery period, and correct their cognitive level. |
