| Effects of high-frequency rTMS on COPD patients with tobacco dependence |
| |
| DOI： |
| EN KeyWords: chronic obstructive pulmonary disease repetitive transcranial magnetic stimulation tobacco dependence |
| Fund Project:国家重点研发计划（2022YFF0710800）；国家自然科学基金（82000038）；广东省基础与应用基础研究基金自然科学基金面上项目（2022A1515010052）；广东省基础与应用基础研究基金区域联合基金青年基金项目（2021A1515111105）；南京市卫生科技发展专项基金（YKK20171） |
| 作者 | 单位 | | 陈子 | 南京医科大学第一附属医院呼吸与危重症医学科,南京 210029 | | 吴迪 | 南京医科大学第一附属医院康复医学中心,南京 210029；南京医科大学康复医学院,南京 210003 | | 李琴 | 广州市第一人民医院,广州 510180 | | 程清 | 南京市栖霞区医院（江苏省人民医院栖霞康复院区）康复科,南京 210046 | | 葛林阳 | 南京医科大学第一附属医院呼吸与危重症医学科,南京 210029；南京市高淳人民医院,南京 211300 | | 徐双兰 | 南京医科大学第一附属医院呼吸与危重症医学科,南京 210029 | | 殷稚飞 | 南京医科大学第一附属医院康复医学中心,南京 210029；南京医科大学康复医学院,南京 210003 |
|
| View Counts: 7846 |
| PDF Download Counts: 9322 |
| EN Abstract: |
| Objective: To investigate the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) on moderate to severe chronic obstructive pulmonary disease (COPD) patients in stable stage with tobacco dependence. Methods: A total of 60 COPD patients were randomly divided into control group (n=30) and treatment group (n=30). The control group was given routine medication, lifestyle intervention, smoking cessation education, and sham rTMS. On the basis of routine medication, lifestyle intervention and smoking cessation education, the treatment group received high-frequency rTMS on the left dorsolateral prefrontal cortex (DLPFC) combined with smoking cues. Smoking craving (VAS), urinary cotinine concentration (UC), Pittsburgh Sleep Quality Scale (PSQI), 6-min walking test (6MWT) and the Medical Outcome Study Short Form 36 (SF-36) were assessed before and after treatment of 5 weeks. Results: Finally, 57 patients (26/27) completed the whole intervention, and the results were included in statistical analysis. After treatment, VAS score, UC, PSQI score, and 6MWD in the treatment group were significantly improved as compared with those before treatment (P<0.05), and significantly better than those in the control group ［VAS (P<0.05), UC (P<0.05), PSQI (P<0.05)］. SF-36 scores of role-emotional (RE) (P<0.05), vitality (VT) (P<0.05), mental health (MH) (P<0.05) and general health (GH) (P<0.05) were significantly improved as compared with those before treatment, and significantly better than those in the control group ［RE (P<0.05), VT (P<0.05), MT (P<0.05), GH (P<0.05)］. Conclusion: High-frequency rTMS can improve smoking craving, cigarette consumption, exercise endurance and quality of life in patients on moderate to severe COPD patients in stable stage with tobacco dependence. |
|
查看全文
Download PDF Reader HTML Full Text |
| Close |
|
|
|
