| Impacts of duloxetine combined with repetitive transcranial magnetic stimulation on neurotransmitters and cognitive function in patients with severe depression |
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| DOI： |
| EN KeyWords: duloxetine repetitive transcranial magnetic stimulation major depressive disorder neurotransmitter cognitive function |
| Fund Project:河北省医学科学研究课题计划（20221652） |
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| EN Abstract: |
| Objective: To investigate the impacts of duloxetine combined with repetitive transcranial magnetic stimulation on neurotransmitter levels and cognitive function in patients with severe depression. Methods: A total of 200 patients with severe depression were randomly grouped into the control group and the combined group. The control group was treated with duloxetine hydrochloride enteric-coated capsules, and the combination group was treated with repeated transcranial magnetic stimulation on the basis of the control group. The curative effect and the cognitive function and neurotransmitter levels of the patients after treatment were compared between the two groups. Results: The total effective rate of combination group was higher than that of control group (P<0.05). The scores of Hamilton Depression Scale (HAMD) and repeatable battery for the asessment of neuropsychological status (RBANS) before and after treatment were significantly different between the two groups (P<0.05). After 6 weeks of treatment, HAMD scores in combination group were lower and RBANS scores were higher than those in control group (both P<0.05). The serum levels of gamma-aminobutyric acid (GABA), 5-hydroxytryptamine (5-HT) and dopamine (DA) in combination group were higher than those in control group, and there was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: Duloxetine combined with repetitive transcranial magnetic stimulation can increase the levels of GABA, 5-HT, DA and other neurotransmitters in patients with severe depression, and improve cognitive function. |
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