| Objective: To explore the efficacy of high frequency repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training in the treatment of executive dysfunction after stroke. Methods: Totally, 60 patients with executive dysfunction after stroke were randomly divided into control group (n=30) and observation group (n=30). The control group was treated with cognitive training and sham stimulation, and the observation group was treated with high frequency (10 Hz) rTMS combined with cognitive training for 6 weeks. The executive function was assessed by frontal lobe function rating scale (FAB), Tower of Hanoi Test (TOH) and wiring Test A (TMT-A) before and after treatment, and the latency and amplitude of event-related potential P300 were evaluated at the same time. Results: There was no significant difference in FAB score, TOH score, TMT-A score, P300 latency and amplitude between the two groups before treatment. At 6th week after treatment, the FAB score of the two groups was higher, the TOH score and TMT-A score were lower, the latency of P300 was shorter, and the amplitude was higher than those before treatment. After treatment, the FAB score was higher, the TOH score and TMT-A score were lower in the observation group than those in the control group. The latency of P300 was shorter and the amplitude of P300 was higher in the observation group than those in the control group. Conclusion: High frequency rTMS combined with cognitive training can effectively improve the executive function of stroke patients. P300 can evaluate the executive function of stroke patients from the point of view of neuroelectrophysiology. |
