| Objective: To systematically evaluate the efficacy and safety of exercise in treatment of amyotrophic lateral sclerosis patients with physical dysfunction. Methods: Randomized controlled studies of exercise training in the treatment of ALS were included in the Chinese and English database. The quality of literature and the risk of bias were evaluated by Cochrane Risks of Bias. The outcome index data were evaluated by merger rate and 95%CI. Results: A total of 11 English articles were included, including 481 patients with ALS. Endurance training, resistance training, aerobic exercise and breathing training apparatus were carried out in experimental group, while simple joint traction and non-resistance breathing training apparatus were used in the control group. The results showed that the ALSFRS-R score in the experimental group from 1 to 3 months was better than that in the control group ［MD=-0.68, 95%CI (-2.01, 3.40), Z=7.66, P<0.01］. There was no significant difference in ALSFRS-R score, FVC% predicted value, ALSSQoL-R quality of life score, FSS score from 0 to 3 months, FSS score from 6 to 10 months, total muscle strength score of extremities, total muscle strength score of upper limb and total muscle strength score of lower limbs between two groups. Conclusion: The short-term rehabilitation exercise of 1-3 months can improve the overall function of ALSFRS-R scale in early and middle stage. However, the clinical benefits of long-term rehabilitation need to be supported by large-sample and high-quality clinical studies. |
