| Efficacy of tDCS in different cranial parts of the brain in the treatment of frozen gait in Parkinson’s disease |
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| DOI： |
| EN KeyWords: Parkinson’s disease frozen gait transcranial direct current stimulation primary motor cortex left dorsolateral prefrontal cortex |
| Fund Project:2022年度新乡医学院第一附属医院青年培育基金项目（QN-2022-B13） |
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| EN Abstract: |
| Objective： To observe the clinical effect of transcranial direct current stimulation (tDCS) on frozen gait in Parkinson’s disease（PD）. Methods：From January 2023 to June 2023, a total of 72 PD patients hospitalized in the First Affiliated Hospital of Xinxiang Medical University were selected and divided into control group, M1 group and L-DLPFC group by a random number table method, with 24 cases in each group. In the M1 placed group，the anode was on the M1 scalp of the dominant hemisphere. In the L-DLPFC group，the anode was placed on the DLPFC scalp of the dominant hemisphere. The cathodes were placed in the contralateral supraorbital fissure. The stimulation intensity of M1 group and L-DLPFC group was 2 mA for 20 min every time. The position of the electrodes in control group was the same as that in M1 group, and the stimulation was given only 2 mA for 1 min. The stimulation was given for 5 consecutive days. Three scales such as MDS-UPDRS, FOG Score and TUGT were used to evaluate the effects of treatment on day 0 and day 5. Results：MDS-UPDRS Ⅲ, FOG score and TUGT time after treatment in M1 group and L-DLPFC group were significantly reduced as compared with those before treatment (P<0.05). Compared with control group, MDS-UPDRS Ⅲ and FOG scores and TUGT time in M1 group and L-DLPFC group were significantly decreased after the treatment(P<0.05).There was no statistically significant difference in the MDS-UPDRS Ⅲ and FOG scores and TUGT time between the M1 group and L-DLPFC group at the same time points. Conclusion：The tDCS in dominant hemispheres (M1 and L-DLPFC) can improve the frozen gait of patients with PD in a short time and improve the quality of life. |
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