| Objective: To explore the application effect of respiratory rehabilitation exercises on non-invasive ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods: In total, 78 patients with acute exacerbation of COPD were randomly divided into the control group （n=39）and the observation group （n=39）. The control group received anti-infection treatment, phlegm reduction, nutritional support, oxygen therapy, non-invasive ventilation, and routine intervention guidance such as maintaining respiratory tract patency, strengthening psychological intervention, and persuading smoking cessation. The observation group received respiratory rehabilitation exercises on the basis of the control group. The sputum score, CAT questionnaire score, mMRC score, and lung function index level of the two groups before and after intervention were compared. The lung function index included maximum expiratory mid segment flow (MMEF), first second forced expiratory volume (FEV1), percentage of first second forced expiratory volume to estimated value (FEV1% estimated value), FEV1/forced vital capacity (FEV1/FVC). C-reactive protein (CRP) and arterial blood gas index levels ［including partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), etc.］ were determined. Results: After 8 weeks of intervention, expectoration score and CAT questionnaire score in two groups were significantly lower than before intervention (P<0.05), and those in the observation group were lower than in the conventional group (P<0.05); mMRC score and CRP level in two groups were significantly lower than before intervention (P<0.05), and those in the observation group were lower than the conventional group (P<0.05); The levels of FEV1, FEV1% pred, FEV1/FVC, MMEF and other pulmonary function indexes in two groups were significantly higher than those before intervention (P<0.05), and those in the observation group were higher than in the conventional group (P<0.05); The levels of PO2 and PCO2 in two groups were improved as compared with those before intervention (P<0.05), and those in the observation group were superior to the conventional group (P<0.05). Conclusion: The application effect of respiratory rehabilitation exercises in patients with acute exacerbation of COPD through non-invasive ventilation is significant. It can not only effectively improve the patient’s respiratory, pulmonary ventilation function, and blood gas staging indicators, but also reduce the level of inflammatory factors in the body, thereby comprehensively improving their prognosis. |
