| Objective: To study characterization of dynamic regional homogeneity (dReHo) changes in the language network of Broca aphasia (BA) after stroke based on resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Totally, 21 cases of Wei and Chinese BA patients as well as 28 cases of healthy people matched with their gender, age, and education level, were selected. The 49 study subjects were divided into 4 groups: control group (a healthy group of Uygur and a healthy group of Chinese speakers); observation group (a group of Uygur speakers patients and a group of Chinese speakers patients). The 4 groups were given resting-state functional magnetic resonance scans after the linguistic behavioural assessment. dReHo was calculated after pre-processing the image data. The two-factor analysis of covariance was used to obtain the brain regions where there was an interaction between aphasia and language, and a bias correlation analysis was performed between brain areas with abnormal temporal variability in dReHo and language behavioural in patients with Uygur and Chinese BA. Results: There was an interaction among the four study groups for temporal variability of dReHo in the left inferior orbital frontal gyrus, the left hippocampus and the left supramarginal gyrus. The temporal variability of dReHo in the left inferior orbital frontal gyrus was higher in the Uygur patient group than in the Uygur healthy group and the Chinese patient group (P<0.05), that in the left hippocampus was lower in the Uygur patient group than in the Uygur healthy group and the Chinese patient group (P<0.05), that in the left inferior orbital gyrus was lower in the Chinese patient group than in the Chinese healthy group and the Uygur patient group (P<0.05), that in the left hippocampus in the Chinese patient group was higher than that in the Chinese healthy group and the Uygur patient group (P<0.05), and that in the left supramarginal gyrus was lower in the Chinese patient group than that of the Chinese healthy group and the Uygur patient group (P<0.05). The temporal variability of dReHo in the left inferior orbital frontal gyrus was positively correlated with word naming (P<0.05) and name address (P<0.05) in the Uygur patient group. The temporal variability of dReHo in the left hippocampus was positively correlated with dictation (P<0.05) in the Chinese-speaking BA patients. Conclusion: Differences exist in the changes of dReHo in the functional brain regions of language in resting state in Uygur and Chinese BA patients. Among them, the enhanced temporal variability of dReHo in the left inferior orbital frontal gyrus may play a compensatory role in the phonological processing of Uygur BA patients, while the enhanced temporal variability of dReHo in the left hippocampus may be related to the recovery of language function in Chinese BA patients. |
