| Objective: To explore the therapeutic effect of probiotic supplements on improving abnormal behavior problems in autistic patients by Meta-analysis. Methods: CNKI, Wanfang Medical Network, CBM, PubMed, Cochrane Library, Web of Science, Embase and other databases were searched by a computer. The publication time of the retrieved literature was from the establishment of the database to April 15, 2023. The quality of the included literature was evaluated by the Cochrane risk bias assessment scale. The outcome indicators of the study included the Autism Behavior Scale (ABC), the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Response Scale (SRS), the Autism Treatment Assessment Scale (ATEC), and the Autism Diagnostic Observation Schedule Second Edition (ADOS-2). RevMan 5.4 software was used to analyze the included literature data. Results: A total of 11 articles were included in the meta-analysis, including 1 Chinese article and 10 foreign articles. The sample size was 469 cases. The results of Meta-analysis showed that the abnormal behavior problem related assessment scale score in the observation group was better than that in the control group after treatment (SMD = -0.32, 95 % CI-0.48--0.16, P<0.0001 ), and the difference between the observation group and the control group was statistically significant. Conclusion: According to the results of meta-analysis, it can be seen that probiotics supplements have a certain therapeutic effect in improving the abnormal behavior problems of autistic patients. It is feasible to treat the abnormal behavior problems of autistic patients with probiotics supplements. |
