| Objective: To investigate the predictive value of 6-minute walking test(6MWT) in disease progression of patients with idiopathic pulmonary fibrosis (IPF). Methods: All 215 patients with IPF were selected. Patients were followed up for 1 year, and lung function and 6MWT parameters were collected at baseline and 1 year later. After 1 year of follow-up, patients were divided into a progressive group (132 cases) and a non-progressive group (83 cases) according to whether disease progression occurred. Pearson correlation analysis was used to analyze the correlation between 6MWT parameters and lung function parameters. Multivariate Logistic regression was used to analyze the risk factors affecting IPF disease progression. ROC curve of IPF disease progression was drawn, and cutoff value of disease progression was predicted by ROC curve analysis. Results: Compared with the non-progression group, the baseline 6MW distance (6MWD), R-SPO2 and E-SPO2 were lower, and the probability of resting and exercise hypoxemia was higher (P<0.01). 6MWD, R-SPO2 and E-SPO2 were positively correlated with FVC, FVC%, DLCO, DLCO% and VC (P<0.05). Binary Logistic regression analysis showed that 6MWD, E-SPO2 and FVC% were independent risk factors for disease progression in patients with IPF. The cut-off value of 6MWD was 398m, the area under ROC curve for assessing disease progression in IPF patients was 0.779 (95%CI: 0.717-0.841), the sensitivity was 75%, and the specificity was 70%. The cutoff value of E-SPO2 was 92%, the area un- der the ROC curve for assessing IPF disease progression was 0.716 (95%CI: 0.648-0.784), the sensitivity was 55%, and the specificity was 78%. Conclusion: Baseline 6MWD and blood oxygen saturation in patients with IPF progression were significantly lower than those in the non-progression group, and were closely correlated with disease severity in patients with IPF. 6MWD and SPO2 could be used as an important basis for the assessment of disease progression in IPF. |
