| Objective: To observe the clinical efficacy of delayed encephalopathy of carbon monoxide poisoning after synchronized hyperbaric oxygen therapy with transcranial repetitive needle stimulation therapy. Methods: The patients with delayed encephalopathy of carbon monoxide poisoning were divided into observation group (n=30) and control group (n=30) according to the randomized numerical table method. The observation group was treated with transcranial repetitive needle stimulation therapy synchronized with hyperbaric oxygen therapy, and the control group was treated with hyperbaric oxygen therapy. After 8 weeks of continuous treatment, Montreal Cognitive Assessment Scale (MoCA), modified Barthel index (MBI), electroencephalogram (EEG) and serum calcium-binding S100B were used to compare the cognitive function, daily living ability and EEG of the patients. The correlation between serum index S100B and GCS and MoCA scores of patients was analyzed. Results: After 8 weeks of treatment, MoCA and MBI scores in 2 groups were significantly higher than those before treatment (P<0.01), and MoCA and MBI scores in observation group were significantly higher than those in control group (P<0.01). There was no significant difference in EEG in the control group before and after treatment, while there was a statistically significant difference in EEG improvement in the observation group before and after treatment (P<0.01). After treatment, the EEG results in the observation group were better than those in the control group and those of the observation group (P<0.01). The serum S100B levels after treatment in the observation group were lower than those before treatment and control group (P<0.01). There was no correlation between serum S100B and GCS score in the observation group, and serum S100B was positively correlated with MoCA after treatment (P<0.01). Conclusion: Transcranial repeated acupuncture therapy with hyperbaric oxygen in the treatment of delayed encephalopathy caused by carbon monoxide poisoning can improve the cognitive function and the ability of daily living, alleviate the abnor-mal EEG, and reduce the level of serum S100B. With the progress of treatment, the improvement of patients’ cognitive function is positively correlated with serum S100B. The serum S100B has certain value in evaluating curative effect and prognosis of disease. |
