| Objective: To investigate the clinical effect of inspiratory muscle training (IMT) combined with aerobic training on patients with heart failure with preserved ejection fraction (HFpEF). Methods: A total of 97 patients with HFpEF in our hospital from January 2022 to January 2023 were selected and randomly divided into a control group and a study group using a computer-generated random number table method, with 48 cases in the control group and 49 cases in the study group. Both groups received standardized anti-heart failure drug therapy. On this basis, the control group received aerobic training therapy, while the study group received IMT combined with aerobic training therapy. The cardiopulmonary endurance indicators ［forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak oxygen uptake (peakVO2), anaerobic threshold (AT), 6 minute walk distance (6 MWD)］, non-invasive hemodynamic indicators ［stroke volume (SV), cardiac output (CO), cardiac output index (CI)］, peripheral muscle strength (number of chair sit-stands in 30 s), quality of life ［Minnesota Life Quality Heart Failure Questionnaire (MLHFQ)］, maximal inspiratory pressure (MIP), N-terminal pro-brain natriuretic peptide (NT-proBNP) level, prognosis ［major adverse cardiovascular events (MACE), heart rate recovery at 1 min after exercise, VE/VCO2 slope, OUES］ were compared between the two groups. Results: After 3 months of treatment, the FEV1, FVC, peakVO2, AT, and 6MWD in both groups were higher than those before treatment (P<0.05), and those in the study group were higher than those in the control group (P<0.05). After 3 months of treatment, the CO, SV, and CI in both groups were higher than those before treatment (P<0.05), and those in the study group were higher than those in the control group (P<0.05). After 3 months of treatment, the serum NT-proBNP levels in both groups were lower than those before treatment (P<0.05), and those in the study group were lower than those in the control group (P<0.05). After 3 months of treatment, the number of chair sit-stands in 30 s and MIP in both groups were greater than those before treatment (P<0.05), and those in the study group were higher than those in the control group, while the MLHFQ score in both groups was lower than that before treatment (P<0.05), and that in the study group was lower than that in the control group (P<0.05). After 3 months of treatment, the incidence of MACE and VE/VCO2 slope in the study group were lower than those in the control group, while the heart rate recovery at 1 min after exercise and OUES were higher than those in the control group (P<0.05). Conclusion: The treatment of HFpEF patients with IMT combined with aerobic training can more effectively promote the improvement of cardiopulmonary function, peripheral muscle strength, and exercise endurance. |
