| Characteristics of exercise tolerance and ventilatory efficiency in patients with non-small cell lung cancer complicated with coronary heart disease |
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| DOI：10.3870/zgkf.2025.04.006 |
| EN KeyWords: non-small cell lung cancer coronary artery disease cardiopulmonary exercise testing ventilatory efficiency exercise tolerance |
| Fund Project:徐州市科技计划项目（KC20136） |
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| View Counts: 569 |
| PDF Download Counts: 393 |
| EN Abstract: |
| Objective: To explore the characteristics of cardiopulmonary function during cardiopulmonary exercise testing (CPET) in patients with non-small cell lung cancer (NSCLC) complicated with coronary heart disease (CHD). Methods: From November 2020 to June 2022, a total of 60 patients with NSCLC complicated with CHD who were admitted for the first time to the Department of Thoracic Surgery at Xuzhou Central Hospital were selected as the experimental group. Then, using propensity score matching with a ratio of 1∶1 in the Department of Thoracic Surgery database and electronic medical record database, 60 patients with pure lung cancer (non-NSCLC CHD group) were matched as the control group, with matching criteria including gender, age, body mass index, smoking history, exercise habits, lung cancer pathological type, and clinical stage. The specific indicators of CPET were collected from both groups for comparative analysis, and the experimental results were observed. Results: Comparison of core indicators of CPET between the two groups revealed that in the NSCLC-CHD group, peak WR, peak VO2, peak VO2/pred%, and peak VO2/kg were lower than those in the non-NSCLC CHD group, while VE/VCO2slope and VE/VCO2nadir were higher than those in the non-NSCLC CHD group. The differences between the two groups were statistically significant (P<0.05). There was no statistically significant difference in AT, peak O2 pulse, and RERpeak between the two groups (P<0.05). Comparison of four stage indexes of CPET between the two groups showed that VO2 (peak), VCO2 (peak), PETCO2 (four stages) and heart rate recovery value (1-4 mins) in NSCLC-CHD group were lower than those in non-NSCLC CHD group, while VE/VCO2 (peak value), heart rate (warm up, AT) were higher than those in non-NSCLC CHD group. The difference was statistically significant (P<0.05). The comparison of static lung function indicators between the two groups indicated that in the NSCLC-CHD group, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, maximum voluntary ventilation (MVV), peak expiratory flow (PEF), and their percentage of predicted values (FEV1%, FVC%, MVV%, PEF%) were all lower than those in the non-NSCLC CHD group (P<0.05), and the differences were statistically significant. Conclusion: Exercise tolerance and ventilation efficiency of NSCLC-CHD patients were worse than those without CHD. CPET can provide a basis for pre-pneumonectomy risk assessment in NSCLC patients with CHD. |
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