| Objective: To compare the effects of different frequencies of repetitive transcranial magnetic stimulation on patients with Parkinson’s disease (PD) by network Meta-analysis. Methods: Randomized controlled trials of rTMS on Parkinson’s patients were retrieved from CNKI, Wanfang database, VIP, Chinese biomedical literature database, PubMed, Embase, Cochranelibrary, Web of science and other databases. The search was from January 1, 2014 to June 1, 2024. Revman was used to evaluate the quality of the included studies. R software and Stata were used for data analysis. Results: A total of 16 articles were included in the analysis, including 959 PD patients. The frequency of rTMS included 0.1 Hz, 1 Hz, 5 Hz, 10 Hz, 20 Hz and 25 Hz. The results of network Meta-analysis suggested that 0.1 Hz rTMS, 1 Hz rTMS and 5 Hz rTMS could improve unified Parkinson’s disease rating scale part III（UPDRS III）score, 1 Hz rTMS and 5 Hz rTMS could improve timed up and go test（TUG）score, 1 Hz rTMS, 5 Hz rTMS and 10 Hz rTMS could improve Hamilton depression scale（HAMD）score. 5 Hz rTMS and 20 Hz rTMS could improve the Parkinson’s disease questionnaire-39（PDQ-39）score of patients, and 1 Hz rTMS, 5 Hz rTMS and 20 Hz rTMS could improve the scales for outcomes in Parkinson’s disease-autonomic（SCOPA-AUT）score of patients. 5 Hz rTMS had the best effect on UPDRS III, TUG, HAMD and SCOPA-AUT, and 20 Hz rTMS had the best effect on PDQ-39. Conclusion: Based on the current research, we can conclude that rTMS can improve UPDRS III, TUG, HAMD, PDQ-39 and SCOPA-AUT in PD patients, and 5 Hz rTMS has the best effect on UPDRS III, TUG, HAMD and SCOPA-AUT, and 20 Hz rTMS has the best effect on PDQ-39. |
