Abstract
Effect of iTBS combined with median nerve electrical stimulation on post-stroke cognitive impairment
  
DOI:10.3870/zgkf.2025.06.002
EN KeyWords: post-stroke cognitive impairment  intermittent Theta burst stimulation  median nerve electrical stimulation  electroencephalogram  power spectral density  Montreal cognitive assessment  Loewenstein occupational therapy cognitive assessment
Fund Project:徐州市科技局重点研发计划(社会发展)-医药卫生面上项目(KC23190)
作者单位
陈秋宇 1.徐州医科大学第二临床医学院江苏 徐州 2210002.徐州医科大学附属徐州康复医院江苏 徐州 221003 
王世雁 2.徐州医科大学附属徐州康复医院江苏 徐州 2210033.徐州市中心医院康复科江苏 徐州 221003 
巩尊科 2.徐州医科大学附属徐州康复医院江苏 徐州 2210033.徐州市中心医院康复科江苏 徐州 221003 
林子芊 1.徐州医科大学第二临床医学院江苏 徐州 2210002.徐州医科大学附属徐州康复医院江苏 徐州 221003 
王翔 2.徐州医科大学附属徐州康复医院江苏 徐州 221003 
陈晓宇 2.徐州医科大学附属徐州康复医院江苏 徐州 221003 
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EN Abstract:
  Objective: To investigate the influences of intermittent Theta burst stimulation (iTBS) in combination with median nerve electrical stimulation (MNS) on the cognitive function of patients with post-stroke cognitive impairment (PSCI). Methods: Totally, 45 patients with PSCI were chosen as the research subjects and were categorized into the combined treatment group, the iTBS group, and the control group via the random number table method, with 15 cases in each group. All the patients in the three groups received conventional rehabilitation therapy. Based on this, the combined treatment group received both MNS and iTBS treatment, the iTBS group received only iTBS treatment, and the control group received conventional rehabilitation treatment. iTBS, MNS, and conventional rehabilitation treatment were all provided once a day, 5 times a week, for a total duration of 4 weeks. Before and after the treatment, the Montreal Cognitive Assessment Scale (MoCA), the Loewenstein Occupational Therapy Cognitive Assessment Scale (LOTCA), and quantitative electroencephalogram [including power spectral density (PSD) and slow wave ratio (DTABR)] were employed to compare the therapeutic effects of cognitive function among the three groups. Results: After the treatment, all three groups exhibited improvement on the scores of the MoCA and LOTCA compared to before(P<0.05). Compared with the control group and iTBS group, Moca and LOCTA in the combination group were significantly inscreased (P<0.05). After treatment, The PSD and DTABR combined group and iTBS groups were improved significantly (P<0.05), and the combined group was optimal(P<0.05). Conclusion: The therapeutic effect of iTBS combined with MBS on the cogni-tive function recovery in PSCI patients is better than the single iTBS treatment.
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