Abstract
Effect of taste stimulation on swallowing function
  
DOI:10.3870/zgkf.2025.06.009
EN KeyWords: taste stimulation  swallowing function
Fund Project:海南省自然科学基金项目(NO.820QN402)
作者单位
王莉 1.海南医学院第二附属医院海口 571300 
蒋惠瑜 1.海南医学院第二附属医院海口 571300 
吴秀香 1.海南医学院第二附属医院海口 571300 
朱毅 2.郑州大学第五附属医院郑州450000 
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EN Abstract:
  Preliminary international research has been conducted to improve swallowing function in animals and humans through various sensory stimuli.Among them, as one of the important sensory stimulation means of taste stimulation, there is a lack of detailed reports and related research in our country.The purpose of this paper is to review the effects of taste stimulation on swallowing function. To review the effects of taste stimulation on swallowing function and the progress of clinical research, aiming to providing new strategies and reference for the rehabilitation of swallowing disorders. We included and reviewed articles published before February 2025 on the effects of taste stimulation on swallowing function. Oropharyngeal sensory inputs were important for the initiation and regulation of swallowing motor sequences. Peripheral sensory stimulation strategies, including taste stimulation, have been progressively developed and applied in human and animal studies. Several brain regions activated by taste stimulation were key brain regions overlapping with the swallowing network, such as insula, orbitofrontal cortex, amygdala, cingulate gyrus, anterior central gyrus, posterior central gyrus, and cerebellum. The effect of taste stimuli on swallowing was influenced by age, cognition, genetic taste status (GTS), and saliva. Of the five purely taste stimuli, concentrated acidic stimuli had the best effects on swallowing function, including faster and stronger swallowing muscle activation, prolongation of apnea duration, reduction of airway malabsorption, and increased swallowing frequency. The other four sweet, salty, bitter and savory taste stimuli and complex taste stimuli have been studied in healthy populations and have also been preliminarily shown to have a positive effect on swallowing. However, the overall evidence was limited, and more randomized, controlled, multicenter trials are needed to more closely examine the exact effective dose, concentration, duration of stimulation, and variables affecting efficacy. Most of the evidence supports that gustatory stimulation can have different degrees of favorable effects on swallowing function, and it shows good clinical value and potential, which is worthy of further in-depth exploration and application.
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