| Guqin music therapy combined with repetitive transcranial magnetic stimulation for post-stroke depression |
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| DOI：10.3870/zgkf.2025.07.007 |
| EN KeyWords: post-stroke depression Guqin music therapy repetitive transcranial magnetic stimulation non-pharmacological treatments |
| Fund Project:湖北本科高校省级教学改革研究项目（2023193） |
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| View Counts: 144 |
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| EN Abstract: |
| Objective: To investigate the therapeutic effect of combining Guqin music therapy with repetitive transcranial magnetic stimulation (rTMS) for patients with post-stroke depression. Methods: A total of 70 patients diagnosed with post-stroke depression were randomly assigned to either an experimental group or a control group. Both groups received standard rehabilitation treatments along with rTMS (target site: left dorsolateral prefrontal cortex; frequency: 10 Hz; intensity: 80%-120% motor threshold; duration: 20 min per session; frequency: once daily, 5 times weekly for 6 weeks). Additionally, the experimental group underwent Guqin music therapy (listening to 15 classical pieces of Guqin music for 30 min each session, once daily, 5 times weekly for 6 weeks). During the study period, one and two patients in the experimental group and the control group withdrew from the study at different stages, resulting in a final sample size of 33 patients in the experimental group and 34 patients in the control group.The Hamilton depression scale (HAMD-24) was utilized to assess the depressive symptoms of patients before and after the intervention of 6 weeks. The National Institutes of Health stroke scale (NIHSS) was used to evaluate the degree of neurological deficit. Results: Post-treatment HAMD scores and NIHSS scores for both groups were significantly reduced compared to baseline levels (P<0.01). The block factor, somatic anxiety factor, and sleep disorder factor scores showed significant reductions post-intervention (P<0.01), with the experimental group demonstrating more pronounced improvements relative to the control group. The total effective rate in the experimental group was higher than in the control group. Conclusion: Guqin music therapy combined with rTMS demonstrates a significantly superior effect on post-stroke depression compared to rTMS alone, suggesting its potential as a safe and effective adjunctive treatment. |
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