| Objective: This consensus provides technical guidance for the clinical application of normobaric saturated oxygen therapy (NSOT). Methods: The necessity, design principles, physiological mechanisms, clinical application standards, and safety operation guidelines of saturated oxygen therapy were systematically explained. The changes in tissue oxygen partial pressure were measured under different oxygen therapy methods, providing evidence-based support for clinical oxygen therapy. Results: Based on current literature and experimental data, saturated oxygen therapy significantly enhances tissue oxygen partial pressure compared to nasal cannula oxygen delivery. When compared to high-flow nasal cannula (HFNC) therapy, saturated oxygen therapy achieves superior tissue oxygenation while substantially reducing oxygen consumption. This approach circumvents the inherent risks and contraindications of hyperbaric oxygen therapy (HBOT). It is clinically applicable for emergency management of acute hypoxic encephalopathies (e.g., sudden cardiac arrest, poisoning, shock) and rehabilitation of chronic hypoxic disorders (e.g., traumatic brain/spinal cord injuries, stroke, encephalitis, cutaneous ulcers). Conclusion: NSOT provides a new pathway for oxygen therapy in clinical practice. |
