| Objective: To observe the clinical efficacy of high-flow oxygen therapy combined with prone position ventilation strategy in extubation of tracheotomized non-mechanical ventilation patients after stroke. Methods: 52 patients with post-stroke tracheotomy non-mechanical ventilation were randomly divided into 18 cases in the observation group, 17 cases in the control A group, and 17 cases in the control B group. The extubation strategy of the observation group was high-flow oxygen therapy + prone position ventilation, that of the control A group was conventional oxygen therapy + prone position ventilation, and that of the control B group was high-flow oxygen therapy + conventional postural management. The median time of extubation, average daily sputum volume and sputum character before extubation, clinical lung infection score before and after extubation, pulmonary function and swallowing function before and after extubation were recorded in the three groups, respectively. Results: The median time to extubation in the observation group was 9 d, which was significantly shorter than that in control group A and control group B (P<0.05); the success rate of extubation in the observation group and control group A was higher than that in control group B (P<0.05); the clinical lung infection scores of the patients in the three groups after extubation were lower than that before extubation (P<0.05), and in the observation group, they were lower than that in control group A and control group B (P<0.05); the average daily sputum volume and character of sputum discharge before extubation were higher than that of control group A and control group B (P<0.05); and the mean daily sputum volume and character of sputum discharge before extubation were higher than that of control group A and control group B. The average daily sputum volume before extubation was higher than that of control group A and control group B (P<0.05), and after extubation, the sputum character grading, pulmonary function score and Saeto's dysphagia grade of the observation group were significantly higher than that of control group A and control group B (P<0.05). Conclusion: High-flow oxygen therapy combined with prone ventilation strategy can shorten the extubation time and improve sputum properties, swallowing function and lung function in stroke patients. |