| With the advent of an aging society, the incidence of knee osteoarthritis (KOA) is gradually increasing, becoming an urgent health problem to be solved worldwide. In recent years, autologous platelet-rich plasma (PRP) and allogeneic PRP have gained significant attention for their potential in promoting cartilage repair and reducing joint pain. Several studies have demonstrated the safety and efficacy of autologous PRP in the treatment of KOA, but its efficacy has been questioned due to the lack of standardization of PRP components. Allogeneic PRP, especially cord blood-derived PRP, has distinct characteristics and special population advantages, and despite its relatively short research history, it has also been effectively concluded in the treatment of KOA. However, there is still a lack of a systematic review of the effects, mechanisms and application prospects of the two methods, and their advantages and limitations need to be explored in depth. This article aims to systematically review the existing literature, explore the effects of autologous PRP and allogeneic PRP in the treatment of KOA, analyze their mechanisms, and look forward to future research directions, in order to provide reference for clinical practice. |
