| Effect of transcranial direct current stimulation combined with intraoral low-frequency electrical stimulation for post-stroke dysphagia in the oral phase |
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| DOI：10.3870/zgkf.2025.10.003 |
| EN KeyWords: stroke dysphagia transcranial direct current stimulation intraoral low-frequency electrical stimulation oral phase dysphagia |
| Fund Project:河北省中医药管理局科研计划项目（2019143） |
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| View Counts: 77 |
| PDF Download Counts: 42 |
| EN Abstract: |
| Objective: To investigate the clinical efficacy of transcranial direct current stimulation (tDCS) combined with intraoral low-frequency electrical stimulation in treating oral-phase dysphagia following stroke, providing new therapeutic insights and empirical evidence for enhancing the rehabilitation of post-stroke patients experiencing dysphagia. Methods: A single-center, randomized, controlled, and single-blind clinical trial was conducted to assess the intervention’s effectiveness. A total of 64 patients diagnosed with oral-phase dysphagia after stroke were recruited from the Department of Rehabilitation Medicine. Participants were randomly assigned into two groups: a control group (n=32) and an experimental group (n=32). The control group received transcranial direct current stimulation in combination with conventional swallowing rehabilitation therapy. The experimental group received the same treatment as the control group, with the addition of intraoral low-frequency electrical stimulation. The treatment course lasted for 2 weeks. Key outcome measures included the modified swallowing dysphagia imaging assessment scores（MBSImp）, oral transit time, soft palate elevation time, scores on the swallowing function-specific quality of life scale（SWAL-QOL）, and indicators of nutritional status（total protein, albumin, hemoglobin levels）and body weight. These measures were recorded and analyzed before and after the intervention to evaluate the changes in clinical outcomes. Results: After 2 weeks of treatment, both groups showed improvement in the SWAL-QOL scores, total protein, albumin, hemoglobin, and body weight(P<0.01); the MBSImp scores, oral transit time, and soft palate elevation time were all reduced (P<0.01). The improvements in the SWAL-QOL scores, total protein, albumin, and hemoglobin were significantly greater in the experimental group than in the control group (P<0.01，0.05). The MBSImp scores in the experimental group were lower than those in the control group (P<0.05). Oral transit time and soft palate elevation time in the experimental group were both significantly shorter than those in the control group, with statistically significant differences (P<0.01,0.05). Conclusion: Transcranial direct current stimulation combined with intraoral low-frequency electrical stimulation can promote the recovery of oral motor function, improve oral-phase dysphagia after stroke, and enhance patients’ quality of life. This combined approach demonstrates greater therapeutic benefits than conventional rehabilitation alone, particularly in improving nutritional indicators and reducing key physiological markers of dysphagia. These findings suggest that integrating neuromodulation with targeted intraoral stimulation may serve as a promising and effective rehabilitation strategy for post-stroke dysphagia. |
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