| Objective: To explore the effect of extracorporeal diaphragmatic pacing (EDP) combined with staged rehabilitation training on acute exacerbation of chronic obstructive pulmonary disease (AECOPD), as well as its impacts on blood gas indicators and quality of life of patients. Methods: A total of 94 patients with AECOPD admitted to our hospital were selected and divided into the phase training group and the EDP group by the random number table method. The phase training group was given staged rehabilitation training, while the EDP group was subjected to the combined therapy of staged rehabilitation training and EDP. After the intervention ended, clinical related indicators, blood gas analysis indicators, inflammatory factor levels, quality of life, and adverse event situations were compared between two groups. Results: The EDP group had significantly shorter time for ICU stay, weaning, and hospitalization than the phase training group (P<0.01). The EDP group had significantly higher oxygenation index and arterial partial pressure of oxygen (PaO2) than the phase training group (P<0.05,0.01). The levels of erythrocyte sedimentation rate (ESR), PaCO2, white blood cell count (WBC), acute physiology and chronic health evaluation II (APACHE II), C-reactive protein (CRP), serum D-dimer (D-D), and procalcitonin (PCT) in the EDP group were significantly lower than those in the phase training group (P<0.01). The EDP group had a significantly lower incidence of adverse events than the phase training group (P<0.05). Conclusion: The combined intervention of EDP and staged rehabilitation training in AECOPD patients can effectively enhance diaphragm activity and promote lung function recovery, with ideal results and certain clinical value. |
