| Objective: To investigate the improvement of respiratory function and the effect on neural circuits of multi-target magnetic stimulation based on neural circuit regulation in patients with post-stroke pulmonary infection. Methods: A total of 41 inpatients with post-stroke pulmonary infection were randomly divided into a control group (20 cases) and an experimental group (21 cases) using a random number table. Both groups received conventional treatment for pulmonary infection, while the experimental group was additionally given central combined with peripheral multi-target magnetic stimulation on the basis of conventional treatment. Before treatment, and 1 week and 2 weeks after treatment, the following evaluations were conducted in both groups: inflammatory indicators (white blood cell count, C-reactive protein), chest CT examination, pulmonary function assessment (forced vital capacity, forced expiratory volume in the first second, blood oxygen saturation measurement after a 10-meter walk), surface electromyography of the diaphragm during deep breathing tasks (integrated electromyography, average electromyography value), and before and 2 weeks after treatment.functional near-infrared spectroscopy (fNIRS) imaging was conducted in the experiment group. Results: After 1 week and 2 weeks of treatment, the inflammatory markers in both groups were significantly lower than those at baseline and at week 1 (P<0.05). The cure rates of chest CT examinations in both groups were markedly improved compared with baseline and at week 1 (P<0.05). Pulmonary function assessments and diaphragmatic surface electromyography indices in both groups were significantly higher than those at baseline and week 1 (P<0.05). At the same time points (week 1 and week 2), the experimental group exhibited superior performance in pulmonary function assessments and diaphragmatic surface electromyography indices compared with the control group (P<0.05). After 2 weeks of treatment, fNIRS analysis revealed that the experimental group showed significantly increased blood oxygen concentration in brain regions including the superior frontal gyrus, frontal pole, inferior frontal gyrus, supplementary motor area, premotor cortex, and middle temporal gyrus during deep breathing tasks compared with baseline (P<0.05). Conclusion: Multi-target magnetic stimulation based on neural circuit regulation can significantly improve the respiratory function of patients with post-stroke pulmonary infection, and the recovery process is accompanied by functional remodeling of specific neural circuits. |
