| Objective: To observe the curative effect of transcranial direct current stimulation (tDCS) in combination with cognitive-motor dual task (CMDT) training in treating post-stroke cognitive impairment (PSCI). Methods: From September 2023 to September 2024, 124 PSCI patients who visited our hospital were randomly allocated into the control group (n=62, given CMDT training) and the study group (n=62, given tDCS + CMDT training) via random number table method. The neurotransmitters, cognitive status, motor function, modified Barthel index (MBI) score, and Berg Balance Scale (BBS) score were compared between the two groups before and after the treatment. Results: After the treatment, the plasma dopamine concentration, plasma norepinephrine (NE) concentration, Mini Mental State Examination (MMSE) score, Montreal Cognitive Assessment (MoCA) score, Fugl-Meyer Assessment (FMA)-Upper Limb score, FMA-Lower Limb score, MBI score, and BBS score in both groups were higher than those before the treatment (P<0.05), and the scores in the study group were higher than those in the control group (P<0.05). Conclusion: Compared with simple CMDT training, tDCS combined with CMDT training can significantly improve the cognitive function, motor function, daily living activity ability and balance function of patients with PSCI. The mechanism of its effect may be related to the regulation of dopamine and norepinephrine levels. |
