| Efficacy of combined transcranial dtirect current stimulation and virtual reality therapy using different temporal sequences on upper limb function after stroke |
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| DOI：10.3870/zgkf.2026.03.001 |
| EN KeyWords: stroke transcranial direct current stimulation different temporal sequences virtual reality technology upper limb function |
| Fund Project:徐州市卫生健康委医学科技创新项目(XWKYHT20240064)；徐州市科技局卫生健康面上项目（KC25081） |
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| EN Abstract: |
| Objective: To evaluate the therapeutic effects of transcranial direct current stimulation (tDCS) combined with virtual reality (VR) technology on upper limb motor dysfunction following stroke, using different temporal sequences. Methods: This study selected 60 patients with hemiplegia due to stroke who were hospitalized at our hospital from January 2024 to December 2024. Using a random number table, they were randomly divided into observation group 1, observation group 2, and a control group, with 20 cases in each group. All three groups received conventional rehabilitation treatment and were given the combined treatment of tDCS and VR technology. Observation group 1 received VR therapy followed by tDCS therapy (VR-tDCS), observation group 2 received tDCS therapy followed immediately by VR therapy (tDCS-VR), and the control group received sham tDCS followed immediately by VR therapy (sham tDCS-VR). The same therapist administered the Fugl-Meyer Assessment Upper Extremity (FMA-UE), Motricity Index Upper Limb (MI-UL), and Modified Barthel Index (MBI) to all patients in the three groups before and after treatment. Electroencephalogram (EEG) analysis was performed on all patients in the three groups before and after treatment. Results: Following treatment, the FMA-UE, MI-UL, and MBI scores in all three gro-ups were significantly higher than pre-treatment levels (P<0.01). Compared with the control group, the observation groups had significantly increased scores on all measures (P<0.05). Furthermore, observation group 2 showed significantly higher scores than observation group 1 (P<0.05). EEG analysis before and after treatment showed that the DAR and DTABR values in all three groups were significantly superior to pre-treatment levels (P<0.01). Pairwise comparisons revealed that observation group 2 demonstrated the most favorable outcomes, followed by observation group 1, both of which significantly outperformed the control group (P<0.05).Conclusion: Both standalone virtual reality therapy and combined virtual reality therapy with tDCS effectively improve upper limb function after stroke. However, clinically, sequential treatment with tDCS-VR is recommended for more effective improvement of post-stroke upper limb function. |
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