| Research progress of external diaphragm pacing and its combination therapy in the treatment of chronic obstructive pulmonary disease |
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| DOI：10.3870/zgkf.2026.03.009 |
| EN KeyWords: external diaphragm pacing chronic obstructive pulmonary disease combination therapy |
| Fund Project:国家自然科学基金(82372573、82072551)；上海市卫生健康委员会卫生健康学科带头人项目（2022XD044）；上海市“超级博士后”资助项目（2022510） |
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| EN Abstract: |
| Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by persistent airflow limitation and progressive dyspnea. Its global incidence continues to rise and has become a serious public health problem. Existing treatments mainly rely on drug interventions, but they are limited in improving respiratory muscle function and improving quality of life. It is urgent to explore new non-drug treatment strategies. This article aims to systematically review the research progress of external diaphragmatic pacing (EDP) in the management of COPD, focusing on evaluating its clinical effects and potential mechanisms of independent application and combined intervention, and providing new treatment ideas and evidence-based basis for clinical practice. Relevant Chinese and English literature published in PubMed, Web of Science, and CNKI databases from 2019 to 2025 were systematically searched, and keywords including “external diaphragmatic pacing”, “chronic obstructive pulmonary disease”, “combined therapy” were screened to summarize the application status and research results of EDP. EDP can enhance diaphragmatic contraction function, improve lung function indicators (such as FEV1, FVC), regulate respira-tory drive, and optimize ventilation-perfusion ratio through transcutaneous electrical stimulation of the phrenic nerve, thereby improving exercise endurance and quality of life. Combined with pulmonary rehabilitation, non-invasive ventilation, traditional Chinese medicine exercises, etc., it has a synergistic effect, which helps to enhance respiratory muscle endurance, reduce hospitalization rate, improve psychological state, etc. However, its clinical application still faces challenges such as individualized parameter setting, long-term efficacy evaluation and cost-effectiveness analysis. EDP, as a promising non-drug intervention, shows good potential in the treatment of COPD. In the future, we should strengthen the basic mechanism research, optimize the combined intervention strategy, and carry out high-quality, multi-center randomized controlled trials to promote its standardized and individualized clinical application. |
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