| Efficacy of motion rehabilitation based on feedforward control for patients with cerebral small vessel disease |
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| DOI：10.3870/zgkf.2026.04.003 |
| EN KeyWords: feedforward control sports rehabilitation cerebral small vessel disease limb motor function cognitive function coagulation function |
| Fund Project:河北省卫生健康委员会医学科学研究课题计划项目（20251551） |
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| EN Abstract: |
| Objective: To study the effects of motor rehabilitation based on feedforward control on limb motor function, cognitive function, and coagulation function in patients with cerebral small vessel disease (CSVD). Methods: A total of 82 patients with CSVD were included and divided into the observation group and the control group according to the random number table method, 41 cases in each group. The control group was given cytidine diphosphate choline sodium tablets, atorvastatin calcium tablets, and conventional exercise rehabilitation. The observation group was given drug treatment combined with exercise rehabilitation based on feedforward control. Before and after the treatment, the motor function, balance function and cognitive function of the patients in the two groups were evaluated: the cognitive impairment factors such as serum visinin-like protein-1 (VILIP-1), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), and angiopoietin-like protein 4 (ANGPTL4); coagulation function indicators such as prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen (FIB). Results: Before the treatment, there was no statistically significant difference in any of the above indicators between the two groups. After rehabilitation, the scores of the two groups with the simplified fugel-meyer motor scale (FMA) and the Berg balance scale (BBS) score, mini mental state examination scale score (MMSE) score, Montreal cognitive assessment (MoCA) scores were all higher than those before rehabilitation (P<0.01). After rehabilitation, the FMA score, BBS score, MMSE score and MoCA score in the observation group were all higher than those in the control group (P<0.01). After rehabilitation, the levels of serum VILIP-1, sTREM2 and FIB in both groups were lower than those before rehabilitation, while the levels of serum ANGPTL4, PT and APTT were higher than those before rehabilitation (P<0.01). After rehabilitation, the levels of serum VILIP-1, sTREM2 and FIB in the observation group were lower than those in the control group, while the levels of serum ANGPTL4, PT and APTT in the observation group were higher than those in the control group (P<0.01). Conclusion: Motion rehabilitation based on feedforward control can enhance the limb motor function of patients with CSVD, improve their coagulation function and cognitive impairment factor levels, and increase the cognitive level of patients. |
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