| Advances in the etiology, pathogenesis and clinical management of joint fibrosis |
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| DOI：10.3870/zgkf.2026.04.008 |
| EN KeyWords: arthrofibrosis joint contracture fibroblast |
| Fund Project:国家重点专科建设项目（XKB2023A2001）；北京市“高创计划·登峰青苗春蕾”项目（G202511047） |
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| View Counts: 118 |
| PDF Download Counts: 79 |
| EN Abstract: |
| Arthrofibrosis is a pathological condition characterized by excessive fibrous tissue hyperplasia occurring in or around the joint due to various etiological factors, leading to impaired normal joint function. The exact pathogenesis of arthrofibrosis remains incompletely elucidated, encompassing complex processes such as cellular proliferation, activation of fibrogenic signaling pathways, and extracellular matrix remodeling. These processes may be initiated by multiple inciting factors, including trauma, chronic inflammation, immune stress, and metabolic disorders. Despite advancements in therapeutic approaches, clinical outcomes for arthrofibrosis remain suboptimal. This review systematically synthesized the major etiological factors, pathological mechanisms, and current treatment modalities for arthrofibrosis, while also delineating future research directions and potential therapeutic strategies to enhance both scientific research and clinical management of this condition. |
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